Mr Kena was a resident of Gensi village in Lower Siang district was undergoing treatment at Guwahati for the past one month. He died last night at the age of 52, the sources said.
Mr Kena, who represented Likabali constituency, was first elected to the Legislative Assembly in 2004. He was re-elected to the House from the same constituency in 2009 and 2014.
Mr Kena was elected as Deputy Speaker during Nabam Tuki's government and served as Parliamentary Secretary in the Dorjee Khandu and Jarbom Gamlin governments.
He is survived by his wife, four daughters and two sons. The mortal remains of Mr Kena would be flown to Naharlagun today from Guwahati and then to his native village Gensi where the last rites would be performed tomorrow.
PM expressed grief on the demise of Arunachal Pradesh's Health Minister, Shri Jomde Kena & extended condolences to his family & supporters.— PMO India (@PMOIndia) September 5, 2017
The state government has declared two days state mourning from today and announced a holiday tomorrow.
In his condolence message, Mr Khandu said, "In his demise, our state has lost a seasoned politician and I have lost an elder brother, who was more than a friend."
"On behalf of the people, I convey my deep condolences to the members of his family, friends and well wishers. I pray for his soul to rest in eternal peace," the message added.