Shiv Sena MP Sanjay Raut told the media: "The stampede on the foot overbridge at Elphinstone Road railway station is a public massacre of the people by the government."
He slammed the BJP for the much-touted Bullet Train project and said commuters' safety and security must be accorded top priority.
Other Sena leaders demanded the resignation of Railway Minister Piyush Goyal, a Mumbaikar who took over his new post this month, and sought the scrapping of the Bullet Train project.
Hundreds of Shiv Sena activists shouted slogans against Mr Goyal and Maharashtra Education Minister Vinod Tawde near the KEM Hospital when the two leaders reached there.
In one of the worst tragedies on the Mumbai suburban network, 22 commuters were killed and another 32 were hurt in a massive stampede on a narrow connecting foot overbridge between Elphinstone Road and Parel railway stations.
The calamity sparked off angry reactions on social media, with many questioning lapses vis-a-vis safety and security of commuters even as mega-projects like Bullet Trains are announced.