"One actor had said that his wife wants to live out of India. It was an arrogant statement. If I am poor and my house is small, I will still love my house and always dream to make a bungalow out of it," he said, without naming Mr Khan.
Mr Parrikar was speaking in Pune after releasing the Marathi version journalist-author Nitin Gokhale's book on Siachen.
In November last year, the "PK" actor had joined the chorus against growing atmosphere of "intolerance", saying he was "alarmed" by the number of incidents with his wife Kiran Rao even suggesting that they leave the country.
"When I sit at home and talk to Kiran, she says 'Should we move out of India?' That's a disastrous and big statement for Kiran to make. She fears for her child. She fears about what the atmosphere around us will be. She feels scared to open the newspapers every day.
"That does indicate that there is this sense of growing disquiet, there is growing despondency apart from alarm. You feel why this is happening, you feel low. That sense does exist in me," Mr Khan had said.
According to Mr Parrikar, when the actor made the statement last year, many people had protested against his remark and even uninstalled the mobile application of an online shopping site he was associated with, while the firm had also pulled out the advertisement featuring him.
In an oblique reference to the alleged anti-national sloganeering at JNU earlier this year, Mr Parrikar said those who speak against the nation need to be taught a lesson by people of this country.
"How come people get guts or courage to speak against the country? Such people who speak against the country need to be taught a lesson by the people of this country," he added.
Get Breaking news, live coverage, and Latest News from India and around the world on NDTV.com. Catch all the Live TV action on NDTV 24x7 and NDTV India. Like us on Facebook or follow us on Twitter and Instagram for latest news and live news updates.