Describing himself as the real fighter, real innovator and all-American India, he said: "On my seventh birthday, in 1970, I left India and came to America: to this land of incredible opportunity."
"As a kid, I learned from my parents, teachers, coaches, and friends that what mattered most was Truth - to uncover it, share it and fight for it. That core value is the foundation of the America Dream. And my life has been about fighting for Truth, at every step," Mr Ayyadurai said.
He is currently the Chairman and CEO of the start-up CytoSolve. He has four MIT degrees and is a contributor to BreitBart news, a far-right American news, opinion and commentary website.
However, given Massachusetts is strong Democratic state, political analysts are giving him no chance of winning the race.
In 2009, he was hired by the Council of Scientific and Industrial Research to create a CSIR Tech to establish businesses using the research conducted by country's many publicly owned laboratories. However, the job offer was withdrawn.
Get Breaking news, live coverage, and Latest News from India and around the world on NDTV.com. Catch all the Live TV action on NDTV 24x7 and NDTV India. Like us on Facebook or follow us on Twitter and Instagram for latest news and live news updates.