He will begin the journey from Ramanathapuram -- his hometown -- and later visit people from the districts of Madurai, Dindigul and Sivagangai.
It will mark Mr Haasan's official entry into politics about which he has been making overtures since last year.
"At the commencement of the journey, I intend to announce the name of my political party along with the guiding principles we intend to live by," Mr Haasan said in a statement on Tuesday.
The veteran actor said he intends to challenge the status quo "that has been plaguing the politics of Tamil Nadu for some time now".
Kamal Haasan said the tour was "neither an act of rebellion nor a gathering for glamour". "This is a journey of discovery and learning and an opportunity for me to truly understand my people," said Mr Haasan.
He exhorted the people of Tamil Nadu to "question mediocrity" and "raise the bar" of governance and welfare in the state.
"This journey is intended towards that goal. I begin this journey with your support. Join hands with me to empower our country and state. I will see you soon," Kamal Haasan said.