Weight Loss Drugs In India: The Rise Of GLP-1s In 2025

In 2025, India witnessed a significant shift in obesity management with the launch of GLP-1 receptor agonists (GLP-1s), a class of medications primarily used to manage diabetes and facilitate weight loss. Recently, the blockbuster diabetes drug Ozempic (semaglutide) was launched in India. While it can effectively manage blood sugar levels, Ozempic has gained popularity as a 'weight loss drug' over the past few years. The urgency surrounding their introduction stems from the alarming rates of diabetes and obesity in India. With the prevalence of these conditions, the diabetes weight loss drug is expected to be one of the fastest-growing markets in the pharmaceutical landscape.

Understanding GLP-1s

GLP-1 receptor agonists mimic the action of the glucagon-like peptide-1 hormone, which is involved in the regulation of appetite and insulin secretion. When administered, these medications stimulate insulin production in response to meals, slow gastric emptying, and reduce the feeling of hunger. As a result, they help patients achieve better glycemic control.

Along with blood sugar control, GLP-1s help with weight loss by suppressing appetite. They can help you feel fuller faster and reduce your overall food intake by acting on the appetite centres in the brain. Additionally, it slows down gastric emptying, which promotes the feeling of fullness after eating, leading to decreased calorie consumption. Clinical studies have shown that individuals using GLP-1 agonists can lose 5-15% of their body weight, an achievement that can considerably improve overall health metrics.

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The rising trend

India is known as the diabetes capital of the world, with statistics indicating that over 77 million adults were diagnosed with diabetes in 2021. This number is expected to rise drastically due to lifestyle changes, sedentary habits, and the increasing consumption of high-calorie, low-nutrient foods. Obesity, often considered the root cause of many health complications, is a recognised lifestyle disorder affecting millions of Indians. The need for effective management solutions has become urgent.

However, experts all over the world have highlighted that these drugs are not "magic pills" for weight loss.

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Obesity, a lifestyle disorder

It is crucial to understand that obesity is a complex lifestyle disorder, often influenced by genetic, environmental, and behavioural factors. While GLP-1s can aid in weight loss, they are not the ultimate solution. Effective weight management requires a multifaceted approach that includes dietary changes, regular physical activity, and psychological support.

Sustainable weight loss is typically achieved through lifestyle changes rather than reliance solely on medications. For individuals who have struggled with obesity for years, GLP-1s can be a valuable tool, but they should not replace the foundational aspects of a healthy lifestyle. Additionally, these drugs should only be used after consulting an expert to understand their suitability based on one's current health status.

Are GLP-1s the healthiest way to lose weight?

While GLP-1s provide an avenue for weight loss with tangible results, it is essential to approach their use judiciously. These medications should not replace the basics of healthy living. The best approach to losing weight remains a balanced diet, regular exercise, and psychological well-being.

Furthermore, GLP-1s come with potential side effects, including gastrointestinal issues, risk of pancreatitis, and potential interactions with other medications. As with any pharmacological intervention, individuals must weigh the benefits against the risks and consult healthcare professionals before starting treatment.

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Considerations before using GLP-1s

Before opting for GLP-1s as a weight loss option, there are several considerations to keep in mind:

1. Medical consultation: Always discuss with a healthcare provider to determine if GLP-1s are appropriate for your condition and health history.

2. Lifestyle commitment: Be prepared to commit to a lifestyle change. Medications work best when combined with healthy eating and regular exercise.

3. Monitoring side effects: Be aware of potential side effects, such as nausea or digestive issues, and monitor their impact on your daily life.

4. Long-term use: Understand that sustainable weight management requires long-term lifestyle changes, and medication should be viewed as a supportive measure rather than a standalone solution.

5. Education and support: Seek educational resources and support groups that can guide you through the process of changing habits and improving health.

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Precautions and safety tips:

If you are considering GLP-1s or have been prescribed them, here are some tips for effective and safe use:

• Adhere strictly to the dosage and administration guidelines provided by your doctor.
• If you have diabetes, keep track of your blood sugar levels regularly to avoid hypoglycemia (very low blood sugar levels).
• Combine GLP-1s with a balanced diet rich in whole foods, fruits, vegetables, and lean proteins for maximum benefits.
• Incorporate regular exercise into your routine to enhance weight loss effects and improve overall well-being.
• Monitor for any potential side effects, like nausea or gastrointestinal issues, and report them to your healthcare provider. Regular follow-ups, every 4-6 weeks initially, to check tolerability and weight trend, are recommended.

Obesity is a complex condition which can be effectively addressed by focusing on nutritious eating, regular physical activity, and staying consistent. A holistic approach centred on healthy lifestyle choices can help individuals achieve sustainable results. As the health landscape continues to evolve, GLP-1s offer hope, but they must be part of a broader strategy focused on overall wellness and preventive care.

Disclaimer: This content including advice provides generic information only. It is in no way a substitute for a qualified medical opinion. Always consult a specialist or your own doctor for more information. NDTV does not claim responsibility for this information.