- Infection with reovirus may trigger an immune response
- The team used a mice model to carry out several experiments
- The study was published in the Journal Science
According to a study conducted by the University of Chicago and the University of Pittsburgh School of Medicine, infection with reovirus, a common but harmless virus, may trigger the immune system response to gluten that leads to celiac disease.
The study was published in the Journal Science and it suggests that certain viruses play a role in the development of autoimmune disorders such as celiac disease and type 1 diabetes. This raises a possibility that a vaccine could developed in future to treat celiac disease.
For the study, the team used two different reovirus strains and showed how genetic differences between viruses can change how they interact with the immune system. Both reovirus strains induced protective immunity and did not cause overt disease. However, when given to mice, one common human reovirus triggered an inflammatory immune response and the loss of oral tolerance to gluten, while another closely related but genetically different strain did not.
With inputs from uchicagomedicine.org
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