"This is a battle between barbaric criminals who seek to obliterate human life, and decent people of all religions who seek to protect it," Trump will say in Saudi Arabia, according to excerpts released by the White House.
"This is a battle between good and evil."
Trump's hardline attitude towards what he has previously called "radical Islamic terrorism" was one of the most controversial themes of his election campaign, particularly in the Muslim world.
In his speech in Riyadh, he will instead urge Muslim leaders to confront "the crisis of Islamist extremism".
"Religious leaders must make this absolutely clear: Barbarism will deliver you no glory... If you choose the path of terror, your life will be empty, your life will be brief," he will add.
Trump will also appeal to countries in the Middle East to play their part in fighting extremism.
"America is prepared to stand with you... But the nations of the Middle East cannot wait for American power to crush this enemy for them.
"The nations of the Middle East will have to decide what kind of future they want for themselves, for their countries, and for their children," he will say.
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