Mr Palaniswami's comments at a government event in Thiruvallur come amidst a tussle with sidelined AIADMK (Amma) leader TTV Dhinakaran. Legislators who support Mr Dhinakaran have sought the chief minister's resignation, saying they have lost confidence in him.
Nineteen legislators and the opposition have asked Tamil Nadu Governor CH Vidyasagar Rao to tell Mr Palaniswami to go for a floor test.
Leaders of the DMK, Congress and Left parties even met with President Ram Nath Kovind in Delhi last week with the same request.
"Some are trying to topple this government which follows the path shown by Amma. They are thinking of pulling it down by any means. But as long as true party supporters are with us, nobody can do that," Mr Palaniswami said.