This is the first cabinet-level official's visit to India under the Donald Trump administration.
"The secretary will emphasise that the United States views India as a valued and influential partner, with broad mutual interests extending well beyond South Asia," the Pentagon said in a statement yesterday.
During his two-day visit starting from September 26, the Pentagon chief will participate in a wreath-laying ceremony at the India Gate, and meet the prime minister and Ms Sitharaman.
"The secretary will also express US' appreciation for India's important contributions toward Afghanistan's democracy, stability, prosperity, and security," the Pentagon said.
During the meeting, the two leaders among other issues discussed Pakistan, Afghanistan and terrorism.
They also discussed the strategic relationship between Washington and New Delhi.
PM Modi and President Donald Trump had announced a two plus two strategic and defence dialogue between the two countries at the White House in June after the India-US summit.