"It (Jaitapur power plant) is now at a stage where one cannot go back," Mr Fadnavis told PTI in an interview.
The project was among the 17 pacts signed between the two countries during Prime Minister Narendra Modi's recent visit to France.
The Jaitapur project in Maharashtra's Ratnagiri district, where French company Areva is to set up six nuclear reactors with total power generation capacity of about 10,000 MW, is stuck for long following protests and differences over the cost of electricity to be generated.
"The previous government had started this (Jaitapur nuclear power) project and brought it to a certain level. It is now at a stage where one cannot go back. You cannot indulge in national waste," the Chief Minister said.
"The Shiv Sena has long been opposing the Jaitapur nuclear project. The BJP feels that India requires nuclear power and when the PM does something, he does it for the country's benefit. This project will be completed at any cost now," he said.
According to Shiv Sena, the energy produced from the project will be beneficial for the whole country, but Maharashtra would be at the maximum risk.
Meanwhile, as head of the first BJP-led government in Maharashtra, Mr Fadnavis is aggressively pitching the state as the most preferred investment destination and wants it to regain its position as an economic powerhouse in the country.
Just six months in the top post, the BJP leader said he is seeking maximum investments in IT, manufacturing and agro-processing industries, the sectors which have the potential to create thousands of jobs, and is wooing foreign companies to set up ventures in Maharashtra, India's most urbanised and industrialised state.
Mr Fadnavis, who just returned from a successful investment- scouting visit to Germany, shared his vision about Maharashtra in an interview, where he talked about plans of his government and slammed the erstwhile Congress-NCP Government for not promoting Mumbai as global financial hub.
"A huge positive sentiment has built up with regards to foreign investments. Industries now want to keenly invest in India as they see their growth here. There were some apprehensions due to a legacy of the last 10 years, but with direct interactions with Modi, their apprehensions are fading away," the chief minister said.