While there is no evidence to suggest that existing vaccines do not work on the Omicron variant of SARS-CoV-2, some of the mutations reported may decrease the efficacy of the jabs, the Union Health Ministry said.
It, however, underscored that definitive evidence for the new variant's increased remission and immune evasion is awaited.
The ministry has issued a list of frequently asked questions (FAQs) about the Omicron variant of coronavirus which has been designated by WHO as a ''variant of concern''.
Two cases of the new variant were reported in Karnataka yesterday.
On the possibility of a third wave of COVID-19, the ministry said given its characteristics, it is likely to spread to more countries, including India, but given the fast pace of vaccination in India and high exposure to delta variant as evidenced by high seropositivity, the severity of the disease is anticipated to be low.
Omicron cases are increasingly being reported from countries outside of South Africa and given its characteristics, it is likely to spread to more countries, including India, the ministry said.
"However, the scale and magnitude of the rise in cases and the severity of the disease are still not clear," it said.
"Further, given the fast pace of vaccination in India and high exposure to delta variant as evidenced by high seropositivity, the severity of the disease is anticipated to be low. However, scientific evidence is still evolving," the ministry said.
From the list of FAQs, the ministry, answering to whether the existing vaccines work against the Omicron variant, said, "While, there is no evidence to suggest that existing vaccines do not work on Omicron, some of the mutations reported on spike gene may decrease the efficacy of existing vaccines."
However, vaccine protection is also by antibodies as well as by cellular immunity, which is expected to be relatively better preserved, it said. Hence, vaccines are expected to still offer protection against severe disease and vaccination is crucial and if eligible, one should get vaccinated, it said.
To a question on if the currently used diagnostics methods can detect Omicron, it said the most accepted and commonly used method of diagnosis for SARS-CoV2 is the RT-PCR method.
"This method detects specific genes in the virus, such as Spike (S), Enveloped (E) and Nucleocapsid (N) etc to confirm the presence of the virus. However, in the case of Omicron, as the S gene is heavily mutated, some of the primers may lead to results indicating the absence of the S gene (called S gene drop out).
"This particular S gene drop out along with the detection of other viral genes could be used as a diagnostic feature of Omicron. However, for final confirmation of the omicron variant genomic sequencing is required," the ministry explained.
It further said the WHO declares a variant as Variant of Concern after assessment when there is an increase in transmissibility or detrimental change in COVID-19 epidemiology or increase in virulence or change in clinical disease presentation or decrease in the effectiveness of public health and social measures or available diagnostics, vaccines, therapeutics.
"Omicron has been declared VoC based on the observed mutations, their predicted features of increased transmission and immune evasion and preliminary evidence of detrimental change in COVID-19 epidemiology such as increased reinfections. The definitive evidence for increased remission and immune evasion is awaited," the ministry said.
It stressed that the precautions and steps to be taken remain the same as before.
"It's essential to mask yourself properly, take both doses of vaccines (if not yet vaccinated), maintain social distancing and maintain good ventilation to the maximum possible."
The government is monitoring the situation closely and is issuing suitable guidelines from time to time, it said. The scientific and medical community is geared up for developing and deploying diagnostics, carrying out genomic surveillance, generating evidence about viral and epidemiologic characteristics, and development of therapeutics, it said.
The ministry said variants are a normal part of evolution and as long as the virus can infect, replicate and transmit, they will continue to evolve.
"Further, not all variants are dangerous and most often than not, we don't notice them. Only when they are more infectious or can reinfect people they gain prominence. The most important step to avoid the generation of variants is to reduce the number of infections," it said.
The new variant reported from South Africa on November 24 was called B.1.1.529 or Omicron based on Greek alphabets. It has shown a very large number of mutations, especially more than 30 on the viral spike protein which is the key target of an immune response, the ministry said.
Given the collection of mutations in Omicron, which earlier individually have been associated with increased infectivity and/or immune evasion, and the sudden rise in the number of positive cases in South Africa, the World Health Organization has declared Omicron a ''variant of concern'', it added.
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