Pharma stocks were in limelight with Lupin surging over 4 per cent. Dr Reddy's, Cipla and Aurobindo Pharma rose 1-2 per cent.
US jobs data coming in below par and concerns about a tighter monetary policy gave investors some anxiety. Other Asian markets struggled to recover from the current stand-off between the US and North Korea over the latter's missile launch.
Quarterly earnings numbers are due this month. Investors are also tracking monsoon progress ahead of their next move. The laggards were HDFC Ltd, ICICI Bank, ITC, Tata Motors, Bajaj Auto and Asian Paints, falling by up to 1.10 per cent.
Hong Kong's Hang Seng was down 0.42 per cent while Japan's Nikkei shed 0.14 per cent in their early deals. Shanghai Composite too lost 0.36 per cent. The US Dow Jones Industrial Average ended 0.74 per cent lower yesterday. (With PTI inputs)