The airport is on an advance landing ground or ALG, meant to support operations of small aircraft and some military planes.
A 42-seater ATR aircraft of Alliance Air touched down at Pasighat at 2.15 pm after a 1.5-hour-long flight from Lokpriya Gopinath Bordoloi Airport in Guwahati.
Pema Khandu tweeted minutes after landing at Pasighat airport:
Mr Khandu also tweeted photos of the aircraft along with its crew.
Landed safely at Pasighat airport few minutes ago flying from Guwahati on Alliance Air. Proud to be part of this historic moment. I am extremely thankful to PM @narendramodi ji and @MoCA_GoI for connecting Arunachal with airways. @PMOIndia@BJP4Indiapic.twitter.com/jRUZWABjmX- Pema Khandu (@PemaKhanduBJP) May 21, 2018
"It is a history in making. With this commercial flight, new vistas of economic development have opened in the region. Besides, the flight services will also open up ample opportunities for the tourism industry," the chief minister said after getting out of the plane at Pasighat.
Alliance Air, a subsidiary of state-run carrier Air India, will operate flights on the Kolkata-Guwahati-Pasighat route thrice a week -- Tuesday, Thursday and Saturday.
Arunachal Pradesh has big potential for generating hydro-power and producing a wide range of horticultural and agricultural products, but mobility has always been a bottleneck in the state, Mr Khandu said.
Another airport at Tezu in Lohit district, 306 km from Itanagar, will be ready for flight operations soon, the chief minister said.
"Besides, Zoom Airlines is scheduled to introduce its services in the state soon," he added.
With inputs from PTI