The levels of cystatin C, a measure of kidney function can help in predicting whether a person will age successfully or not. Aging refers to a process of physical, psychological, and social change. Human beings reach a peak of growth and development around their mid 20s. After this there takes place a normal transition that involves various physical and mental changes. 'Successful aging' has been defined as encompassing a clinical state in which major chronic diseases, cognitive impairment, and physical disability are absent. It is believed that the functioning of kidneys is directly related to the process of aging. And that it can tell whether a person is aging successfully or not. To assess the relation between kidney function and the process of aging, American researchers checked cystatin C levels in 2,140 men and women 65 year of age or older who were free of heart disease, chronic lung disease (such as emphysema), and cancer, and also had no serious cognitive or physical problems. During follow-up, which averaged just over 4 years, 873 of these subjects developed cognitive or physical disability, lung disease, heart disease, or cancer. The results showed that the functioning of kidneys could offer clues in identifying people who are prone to unfavourable outcomes due to aging. The lower a person's level of cystatin C, the more successful years of life they had ahead of them. It was found that people with the highest levels of cystatin C had 27 percent fewer successful life years ahead of them as compared to those with the lowest levels. But as to whether kidney function itself is a factor in successful aging, or whether it serves as a marker for related health problems, such as high blood pressure or diabetes, still remains to be found.
Archives of Internal Medicine,
February 2008