Commander Anton Shkaplerov of Roscosmos and flight engineers Norishige Kanai of Japan Aerospace Exploration Agency and Scott Tingle of NASA lifted off from the Baikonur Cosmodrome at 1:21 p.m. local time (0721 GMT/0221 EST).
The crew will gradually approach the station, which orbits about 250 miles (400 km) above Earth, for two days before docking.
Onboard cameras showed crew members making thumbs-up gestures after the blast-off. Also visible was a stuffed dog toy chosen by Shkaplerov's daughter to be the spacecraft's zero-gravity indicator.
Soyuz was safely in orbit about 10 minutes after the launch.
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