The much anticipated trip to Washington will follow a visit to Britain on March 7 for talks with Prime Minister Theresa May.
US President Donald Trump hosted Prince Mohammed in March 2017, just weeks after taking office, and he chose Saudi Arabia for his first official overseas visit as president.
Prince Mohammed, who was named heir in June 2017, is also expected to visit France in the coming weeks.
Saudi Arabia has grown close to its longtime ally Washington under Trump, whose harder line on its arch-rival Iran and softer stance on arms sales are a welcome shift in policy for Riyadh.
Saudi Arabia viewed Trump's predecessor president Barack Obama as too accommodating towards Iran -- particularly on negotiating a 2015 nuclear deal.