The 33-year-old married financier James Matthews, 41, at a ceremony attended by the royal couple and tennis star Roger Federer, as she wore a couture dress by British designer Giles Deacon.
William, the second in line to the throne, arrived with his brother Prince Harry at St Mark's Church in Englefield, a quiet rural village west of London near the Middleton family home.
William's cousin Princess Eugenie also attended, as did 18-time Grand Slam winner Federer and his wife Mirka, reflecting Middleton's keen interest in tennis.
The bride arrived with her father Michael in a Jaguar Mark V open-top car, wearing a high-necked, capped-sleeved dress with a corseted bodice and sweeping skirt, worn with a veil by milliner Stephen Jones.
She received a cheer from around 100 local residents and well-wishers from the village who were invited to watch the event from the green in front of the church.
Local residents were reportedly given wristbands and asked to carry identification.
There was no sign at the church of Harry's girlfriend Meghan Markle, a US actress, although she was reportedly due to attend the evening event.
Harry's love life is a source of much speculation, prompting him last year to issue a rare warning to the media not to harass Markle.
Glass marquee and flypast
Middleton was plunged into the public eye at her sister's wedding, which had an estimated worldwide television audience of two billion.
Pictures of her standing behind the royal bride in a white Alexander McQueen maid of honour's dress filled newspapers for weeks afterwards.
"It is a bit startling to achieve global recognition (if that's the right word) before the age of 30 on account of your sister, your brother-in-law and your bottom," she once wrote.
Since then, she has been a regular fixture on the London social circuit, and is a regular in the royal box at the Wimbledon tennis championships.
After the church service, guests were invited to a reception at a nearby stately home, Englefield House, where a flypast by a World War II-era Spitfire plane was reportedly planned.
A 100,000 euros ($130,000, 115,000 euro) temporary glass marquee has been installed in the garden of Middleton's family home for the evening party, according to reports.
She graduated from Edinburgh University with an English literature degree, before working part-time for her parents' party paraphernalia business.
She has published two books -- a 2012 guide to party planning that was widely mocked for offering glaringly obvious advice, and a healthy recipes charity book. She also had a column for a supermarket magazine.
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