"At Waymo, we have a lot of confidence that our technology would be able to handle a situation like that," John Krafcik told a car dealership conference in Las Vegas on Saturday.
He added that Waymo's vehicles had clocked more than eight million kilometers (4.9 million miles) on routes frequented by pedestrians since 2009 without being involved in a fatal accident.
But he said he was nevertheless troubled by the incident.
An autonomously-operating Uber struck and killed a pedestrian on March 18 in the US state of Arizona.
As a result of the accident, Uber suspended its self-driving tests which it had been conducting in Tempe, San Francisco, Pittsburgh, and Toronto, Canada.
It also raised fears about the future of such cars, which supporters claim will dramatically reduce accidents.
Get Breaking news, live coverage, and Latest News from India and around the world on NDTV.com. Catch all the Live TV action on NDTV 24x7 and NDTV India. Like us on Facebook or follow us on Twitter and Instagram for latest news and live news updates.