According to an independent research institute OdoxaSondages poll, Mr Macron will get 62 per cent votes and Ms Pen to get 38 per cent.
As many as 60% voters in France will be voting for a candidate who was not their first choice. 15% were still undecided on the last day of campaigning in France on Friday.
Many of Ms Pen's supporters fall off the radars of opinion polls as they don't openly express their intent. They fear being labelled racist.
There's a bitter debate among voters on whether a refusal to endorse Mr Macron openly, amounts to playing with fire and pushing France into the hands of an extremist party.
Mr Macron himself acknowledges the uncertainty of Sunday's vote. "I know the French men and women - you don't dictate their choices. Nothing is to be taken for granted."
Abstention and blank voting could still seriously threaten Mr Macron's lead.
"It's an election of frustration. Neither the classic right wing nor the left wing is happy with the two candidates. The radical left isn't happy either. So no one is truly content. Except for the 40% who voted for them from the beginning," said Virginie Martin, political scientist.
Mr Macron's campaign was hit by a massive online hacking attack on Friday. But pre-election media blackout in France means the leaks will not have a major impact on the vote.