"I'll beat Oprah," Trump said of the Oscar-nominated actress and talk show host.
"I like Oprah," he said, adding that he had appeared on her long-running afternoon program.
"I know her very well," he said, before adding: "I don't think she's going to run."
Winfrey's rousing speech at Sunday's Golden Globes Awards ceremony ignited speculation that the billionaire chat show queen is harboring Oval Office ambitions.
Some Democrats -- still reeling from Hillary Clinton's shock loss to Trump in 2016 -- have embraced the idea of having their own celebrity leader.
"I don't think at this point she is actually considering it," said Winfrey's best friend Gayle King, who is also a television personality, however noting that the actress was "intrigued" by the idea of running.
"I also know, after years of watching the Oprah show, you always have the right to change your mind."
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