It will be Xi's first meeting with Trump, whose presidency began on Jan. 20, and comes as the two sides face pressing issues, ranging from North Korea and the South China Sea to trade disputes.
Ministry spokesman Lu Kang made the announcement at a daily news briefing.
He did not give any more details of the meeting agenda, but spoke of the need to see the big picture while fostering mutual interests in trade relations.
"The market dictates that interests between our two countries are structured so that you will always have me and I will always have you," Lu said.
"Both sides should work together to make the cake of mutual interest bigger and not simply seek fairer distribution," he said in response to a question about trade frictions.
Beijing had previously said that preparatory work for the meeting was underway. But it had not yet confirmed the trip, despite western media reports on a scheduled meeting and an announcement by the Finnish government that Xi would make a brief stop in Finland on April 5.
The summit will follow a string of other recent US-China meetings and conversations aimed at mending ties after strong criticism of China by Trump during his election campaign.
US Secretary of State Rex Tillerson ended a trip to Asia this month in Beijing, agreeing to work together with China on North Korea and stressing Trump's desire to enhance understanding.
Beijing is also deeply suspicious of US intentions towards self-ruled Taiwan, which China claims as its own.
During his election campaign, Trump accused China of unfair trade policies, criticised its island-building in the strategic South China Sea, and accused it of doing too little to constrain North Korea.
Trump also incensed Beijing in December by taking a phone call from Taiwanese President Tsai Ing-wen and later saying the United States did not have to stick to the so-called "one China" policy.
He later agreed in a phone call with Xi to honor the long-standing policy and has also written to Xi since seeking "constructive ties."
(Reporting by Christian Shepherd, Writing by Michael Martina, Editing by Simon Cameron-Moore)
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