"I would have sung w @ladygaga if asked," he wrote on the micro blogging website.
While his tweet garnered 73,000 'likes' and a ton of appreciative responses, it was former US President Barack Obama's response that really took the cake.
About five hours ago, Mr Obama took to Twitter to let Mr Bush know that he and Lady Gaga could handle the singing, while the other former presidents tagged in the tweet would handle the donations.
His hilarious rejoinder has garnered over 166,000 'likes' in just a few hours, with many praising him for his efforts towards hurricane relief.
On October 21, all five living former US presidents took part in a benefit concert - One America Appeal - in Texas, to raise money for hurricane relief efforts. A photo of the presidents with Lady Gaga, who performed at the fundraiser, went instantly viral with over 1.5 lakh 'likes' and 39,000 retweets.
Click for more trending news