Ramesh Buchirajam Akkela aka Ramesh Bhai, 44, of Mumbai was arrested in Panama earlier this year and extradited to the US on Thursday.
Senior judge Donetta W Ambrose sentenced Ramesh for the 33-month jail term on Friday after his conviction of mail fraud and money laundering, a court statement said.
According to information presented in the court, Ramesh shipped misbranded drugs from India to re-shippers in the US for distribution - without prescription - to American consumers.
Assistant United States Attorney Shardul S Desai prosecuted the case on behalf of the government.
Ramesh operated an online website that offered prescription drugs, without a prescription, to American consumers. He was indicted on two counts of money laundering, 10 counts of mail fraud, a report said.