Among them is California's Attorney General Kamala Harris, 51, a close confidant of US President Barack Obama. She is expected to be elected to the US Senate and could thus become the first Indian-American woman to enter the upper houses of the US Congress.
Experts are also talking about Ramila Jayapal, 51 who is considered the front runner in the race for a US House of Representatives Seat from Washington State. She would be the first Indian-American woman to be elected to the House.
However, this is not the first time Indian-Americans made it as US legislators.
Dalip Singh Saund was the first Indian-American to be elected to the House of Representatives in the 1950s. It took another 50 years for another Indian-American - Bobby Jindal- to be elected to the Congress. Mr Jindal was elected twice from Louisiana before he went on to become a two-term governor of the state.
His fellow Democrat, Ro Khanna, 40, has raised a record amount of money, and is considered to be running a close race with incumbent Congressman Mike Honda. He narrowly lost the 2014 general elections and is expected to come back stronger this year.
Another Indian-American Raja Krishnamoorthi, 43, is one of the few candidates who has been endorsed by US President Barack Obama. US political experts say he could win a seat to the House of Representatives, since he is running from a seat which is considered to be a Democrat stronghold.
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