At least seven people were killed when a large tractor-trailer blew a tire, jumped a highway median into oncoming highway traffic and slammed into a Greyhound passenger bus, New Mexico State Police said.
Images of Thursday's scene on US media show vast area of debris and a bus missing its front section up to the front tires.
The truck "suffered a tire blowout, causing the semi to cross the median into opposing West-bound traffic" and collide with the bus carrying 48 passengers, New Mexico police said in a statement.
The truck driver however survived the crash with "non-life-threatening injuries."
The accident, near the New Mexico town of Thoreau, took place around noon (1800 GMT) and closed a portion of Interstate 40, a major East-West highway, local officials said.
The bus was heading from Albuquerque, New Mexico to Phoenix, Arizona, local media reported.
(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)