The 18-minute video was filmed in Vatican City and broadcast to the audience at the annual TED 2017 conference in Vancouver.
"The more powerful you are, the more your actions will have an impact on people, the more responsible you are to act humbly," said the pontiff, while seated at a desk.
"If you don't, your power will ruin you, and you will ruin the other."
The comments echoed Francis' frequent themes to not ignore the plight of immigrants, the poor and other vulnerable people
Speaking in Italian with subtitles, Francis urged solidarity to overcome a "culture of waste" that had affected not only food but people cast aside by economic systems that rely increasingly on automation.
TED Talk lectures have grown in popularity, having been viewed cumulatively over 4.6 billion times since going online in 2006.
Other speakers slated to appear at the annual conference this week include tennis superstar Serena Williams and entrepreneur Elon Musk.
(Reporting by Amran Abocar, Editing by Michael Perry)