A brief Vatican statement said Cardinal Gerhard Ludwig Mueller's five-year mandate as head of the Congregation for the Doctrine of the Faith, a department charged with defending Catholic doctrine, would not be renewed.
The position is the most important one that a pope fills in the Vatican hierarchy after the Secretary of State. Most incumbents keep it until they retire, which in Mueller's case would have been in six years.
Mueller, 69, who was appointed by former Pope Benedict in 2012, will be succeeded by the department's number two, Archbishop Luis Francisco Ladaria Ferrer.
Ladaria, a 73-year-old Spaniard who, like the Argentine pope is a member of the Jesuit order, is said by those who know him to be a soft-spoken person who shuns the limelight. Mueller, by contrast, often appears in the media.
"They speak the same language and Ladaria is someone who is meek. He does not agitate the pope and does not threaten him," said a priest who works in the Vatican and knows both Mueller and Ladaria, asking not to be named.
Since his election in 2013, Francis has given hope to progressives who want him to forge ahead with his vision for a more welcoming Church that concentrates on mercy rather than the strict enforcement of rigid rules they see as antiquated.
Mueller is one of several cardinals in the Vatican who have publicly sparred with the pope.
Second Conservative Departure In Three Days
His departure follows the high-profile exit of fellow conservative Cardinal George Pell, the Vatican economy minister who took a leave of absence on Thursday to face charges of historical sexual abuse in his native Australia.
In 2015 both were among 13 cardinals who signed a secret letter to the pope complaining that a meeting of bishops discussing family issues was stacked in favour of liberals. The letter was leaked, embarrassing the signatories.
Mueller has criticised parts of a 2016 papal treatise called "Amoris Laetitia" (The Joy of Love), a cornerstone document of Francis' attempt to make the 1.2 billion-member Church more inclusive and less condemning.
In it, Francis called for a Church that is less strict and more compassionate towards any "imperfect" members, such as those who divorced and remarried, saying "no one can be condemned forever".
Conservatives have concentrated their criticism on the document's opening to Catholics who divorce and remarry in civil ceremonies, without getting Church annulments.
Under Church law they cannot receive communion unless they abstain from sex with their new partner, because their first marriage is still valid in the eyes of the Church and therefore they are seen to be living in an adulterous state of sin.
In the document the pope sided with progressives who had proposed an "internal forum" in which a priest or bishop decide jointly with the individual on a case-by-case basis if he or she can be fully re-integrated and receive communion.
After the document was published Catholic bishops in some countries, including Germany, enacted guidelines on how priests could allow some divorced and remarried Catholics to receive the sacraments.
But Mueller has said there should be no exceptions, making him a hero to conservatives who have made the issue a rallying point for their opposition to Francis.
(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)
Get Breaking news, live coverage, and Latest News from India and around the world on NDTV.com. Catch all the Live TV action on NDTV 24x7 and NDTV India. Like us on Facebook or follow us on Twitter and Instagram for latest news and live news updates.