Skripal, recruited by Britain's MI6 in 1995, had "crucial information on how the Russian system works, how they work abroad," a well-informed Czech intelligence source, who spoke on condition of anonymity, told AFP.
Skripal and his daughter were poisoned in England in March in a nerve agent attack that Britain and its Western allies have blamed on Russia.
Moscow has vehemently denied any involvement.
The former Russian spy visited Prague in 2012, according to the website of Czech weekly Respekt.
"Yes, something like that did happen. The participants in the meeting considered it most beneficial," the intelligence source told AFP.
Czech intelligence officials also met Skripal in Britain at least once, according to Respekt.
The New York Times reported this week that in 2016 Skripal also met agents from Estonia, a formerly Soviet-ruled Baltic state that is now an EU and NATO member.
Harrys Puusepp, spokesman for Estonia's Internal Security Service, declined to confirm or deny the report on Wednesday, telling AFP that the agency cannot "comment on our international cooperation".
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