The blazes have destroyed hundreds of houses and forced many Los Angeles-area schools to close.
Flames hopscotched over highways and railroad tracks, and residents rushed to evacuate their homes with only minutes' warning, some leaving behind holiday gifts. People feared for the safety of animals from cats to llamas.
The winds, which blow in hot and dry from the California desert, could reach 75 miles per hour (120 km per hour), authorities said.
The National Weather Service said Santa Ana winds were blowing on Thursday afternoon, and the state CAL FIRE agency said gusty winds and extremely low humidity would continue through Sunday.
"Prepare now to ensure if evacuated you and your family are ready to GO!," CAL FIRE said on Twitter.
North of San Diego, another blaze called the Lilac Fire grew from 10 acres to 500 acres in just a few hours on Thursday, CAL FIRE said. The blaze destroyed two structures and prompted evacuations and road closures. Propane tanks under several houses exploded from the heat, sounding like bombs, according to a Reuters photographer at the scene.
Firefighters and helicopters sprayed and dumped bucketloads of water to try to contain the flames against a hellish backdrop of flaming mountains and walls of smoke.
About 100 firefighters fended off flames in the seaside enclave of Faria Beach, caught between burning mountains and the Pacific Ocean, northwest of Ventura.
Fires spread down the smoking hills, jumping the heavily used U.S. 101 highway, and headed toward clusters of beach houses. Firefighters lined up along a railroad track, the last barrier from the flames.
Surrounded by strong winds and smoke, Songsri Kesonchampa aimed a garden hose at a large pine tree between her Faria Beach house and the fire, attempting to fend off disaster.
"If this tree catches fire, the strong wind will blow the flames towards my house. I need to protect this tree," she said.
As she spoke, a sheriff's car drove by, ordering residents to evacuate. "The fire is here. You must evacuate your homes right now," an officer said over the loudspeaker.
Nearby, Ventura resident Shana Dalton was checking on her friends' house. "One minute the flames were on the mountains and then next thing you know, they jumped the 101 and the train tracks and were right in front of us," she said.
Because of the heavy smoke, the South Coast Air Quality Management District warned residents, especially the elderly, children, pregnant women and people with respiratory diseases, to stay inside.
The Los Angeles Police Department tweeted, "LAPD Working to Save Every Californian, Pets Included" along with a photo of a police officer in a respirator rescuing a cat. The Los Angeles County animal shelter said it was hosting 184 pets including llamas, donkeys and horses while reports said 29 horses were burned to death on Tuesday at a ranch in the Sylmar neighbourhood of Los Angeles.
The Skirball Fire in Los Angeles has forced hundreds of residents in the wooded hills near the Bel-Air neighbourhood to evacuate and charred more than 475 acres (192 hectares).
Jeremy Broekman was camped out at his in-laws' house in Sherman Oaks after evacuating his family of five early Wednesday from their home a mile away from the Skirball fire.
Broekman, who runs a public relations firm from his home office, had just an hour to get his family out of the house, grabbing hard drives and Pokemon cards and leaving behind a pile of Hannukah presents.
He spent Thursday trying to work and checking the news while also caring for his three children, whose schools were closed because of the fire.
"Although we always say we can work remotely with the use of a laptop, when you are displaced like this you are emotionally unbalanced," he said.
Skirball threatened media magnate Rupert Murdoch's Moraga Estate winery. The property was evacuated, with possible damage to some buildings, Murdoch said in a statement, but "We believe the winery and house are still intact."
The Los Angeles Unified School District, the country's second largest with more than 640,000 students, said it closed at least 265 of its nearly 1,100 schools. The University of California Santa Barbara cancelled classes as well.
Utilities cut power to customers in some mountain communities northeast of San Diego and east of Los Angeles to lessen fire danger. The outage could last several days.
The fires are the second outbreak to ravage parts of California this autumn. The celebrated wine country in the northern part of the state was hit by wind-driven wildfires in October that killed at least 43 people, forced some 10,000 to flee their homes and consumed at least 245,000 acres (9,900 hectares) north of the San Francisco Bay area.
The California Department of Insurance said the northern California blazes caused insured losses of more than $9 billion.
(Additional reporting by Dan Whitcomb and Nichola Groom in Los Angeles, Peter Szekely in New York, Brendan O'Brien in Milwaukee and Mike Blake in Lilac, California; Writing by Bill Trott and Cynthia Osterman; Editing by Jeffrey Benkoe, James Dalgleish and Lisa Shumaker)
(This story has not been edited by NDTV staff and is auto-generated from a syndicated feed.)