Mr Bilawal, 29, will contest from the NA-200 seat in Larkana, The Express Tribune quoted President of the Sindh wing of the PPP, Nisar Ahmed Khuhro as saying.
This constituency was previously known as NA-207 from where Mr Bilawal's mother and late prime minister Benazir Bhutto used to contest the polls.
PPP co-chairman Asif Ali Zardari's sister Faryal Talpur won this seat in the last general elections in 2013 defeating Ghinwa Bhutto.
The constituency comprises of Larkana city, Ratodero Taluka and areas that fall under the limits of Aqil town. General elections in Pakistan is expected to be held in July.
After the recent delimitation of the constituencies, this seat has now been renamed as NA-200, the report said.
"We challenge all opposition parties to field their candidates against Bilawal," he said.
"The 2018 elections will be the first for Bilawal and the last for all his opponents," he added.
Mr Khuhro said that they would love to see Bilawal as the next prime minister of Pakistan.
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