Ms Karwal replaced R K Chaturvedi, a Madhya Pradesh cadre IAS officer who was transferred to the National Skill Development Agency, reported the Indian Express.
Mr Chaturvedi was appointed as Chairman of CBSE in July last year.
In last one year, CBSE was drawn into several controversies including the court cases of moderation policy and National Eligibility cum Entrance Test (NEET).
The Secretary (School Education and Literacy), Ministry of Human Resource Development, Government of India is the Controlling Authority of the Board and appoints the Chairman and other Heads of Departments.
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