Dr Saba, pursuing research under Prof Najmul Islam (Department of Biochemistry, JNMC) found that ovalbumin nanosheets, derived from egg whites evoked immune responses and their extended 2D structure facilitated loading of anti-cancer drug doxorubicin.
The paper explains that the extended surface of nanosheets facilitates additional loading of chemotherapeutic drugs making them a platform for combined immunotherapy and chemotherapy procedure for the treatment of cancer and other diseases.
"Amyloid nanosheets are easy to synthesise and act as antigens and adjuvants, curtailing the need for synthesising a delivery system, which entraps the antigens and administers adjuvants," said Dr Saba.
"On subjecting ovalbumin to standard denaturing conditions, I encountered giant protein nanosheets harbouring amyloid like features," she pointed out.
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