The strikes hit Taliban training facilities in Badakhshan province, "preventing the planning and rehearsal of terrorist acts," the Southern Command said in a statement.
The bombing also destroyed vehicles that it said the Taliban took from the Afghan National Army and were turning into vehicle-born explosive devices.
The strikes were carried out in part by a US Air Force B-52 Stratofortress, which dropped 24 guided munitions.
The Southern Command, which oversees US military activities in the Middle East and Afghanistan, said it continues to carry out strikes against the Taliban and its support networks in Helmand Province in the south of the country as well.
Strikes and raids by US and Afghan forces "have resulted in the removal of more than $30 million of Taliban revenue since the campaign began in November, 2017," the Command said.
The number of allies in Afghanistan has actually grown to 41, he said.
"They're there because they believe in the strategy, which means the Afghan boys continue to carry the load for the fighting, but now with advisers that bring the NATO air support and fire support to bear to help them."
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