Francis visited a drab refugee centre on the outskirts of Bologna known simply as "The Hub". Run by a charity, it is home to about 1,000 asylum seekers, most of whom risked their lives crossing the Mediterranean from Africa and the Middle East.
There, they live in grey containers and other forms of temporary housing while awaiting decisions on their asylum requests to be moved to other towns in Italy.
Many of the refugees and migrants are without documents and all wear a plastic yellow bracelet. The pope wore one bearing his name and the number 3900003 on his right wrist. It was given to him by an African refugee.
"Many who don't know you are afraid of you," he told them as a light drizzle fell. "That makes them think they have the right to judge (you) coldly and harshly," he said.
He paid homage to those who "never arrived because they were eaten up by the desert or the sea".
Some 600,000 impoverished migrants and refugees have arrived in Italy in less than four years. In that time, more than 13,000 have died trying to cross the Mediterranean.
Francis, who has made defence of migrants and refugees a major plank of his papacy, also condemned internet trolling against foreigners, saying they had been subjected to "terrible phrases and insults."
"If we look on our neighbours without mercy we risk that even God will look on us without mercy," he said.
Last week, the far-right, anti-immigrant Alternative for Germany (Afd) party surged to third place in a national election, tapping into public disquiet over the arrival of more than a million migrants in Germany over the past two years.
Francis called on more governments to facilitate initiatives backed by the private sector and community groups to set up "humanitarian corridors for refugees in the most difficult situations."
This was a reference to programmes such as one run in Italy by the Rome-based Sant' Egidio peace community, which regularly brings into Italy refugees fleeing the civil war in Syria.
Italy's anti-immigrant Northern League, whose base is in the regions just north of Bologna, has vowed to clamp down on migration from developing countries if it forms part of a coalition government after next year's elections.
(Editing by Mark Potter)
(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)
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