Using characteristically crude language, Duterte teed off against Kim ahead of a regional security meeting in Manila where the hermit state's ballistic missile tests will be a hot agenda item.
"He is playing with dangerous toys and this crazy man, do not be fooled by his face, that chubby face that looks nice," Duterte, 72, said of Kim in a nationally televised speech.
"That son-of-a-whore maniac, if he makes a mistake then the Far East will become an arid land. It must be stopped, this nuclear war, because (if) a limited confrontation blows up here, I tell you the fallout, the soil, the resources. I don't know what will happen to us. We won't be able to plant anything productive."
Under Kim's leadership, Pyongyang has accelerated its nuclear ambitions, in defiance of international condemnation and multiple sets of United Nations sanctions.
North Korea last week conducted its second intercontinental ballistic missile test, which led Kim to boast he could strike any target in the United States.
The ministers will express "grave concern" over North Korea's nuclear missile test, according to a draft copy of the chairman's statement obtained by AFP and scheduled to be released on Tuesday next week at the end of the ASEAN Regional Forum.
Duterte, who won presidential elections last year, has come under fire from foreign leaders over his war on drugs that has claimed thousands of lives and led to warnings by rights groups that he may be overseeing a crime against humanity.
He typically flavours his speeches with crude language and jokes deemed by many to be offensive, including about rape.
Duterte last year called then US president Barack Obama a "son of a whore" for criticising the drug war.