The Cassini spacecraft made its closest approach to Titan today at an altitude of 119,049 kilometres above the moon's surface.
Images and other science data taken during the encounter are expected to begin streaming to Earth soon.
Navigators will analyse the spacecraft's trajectory following this downlink to confirm that Cassini is precisely on course to dive into Saturn at the planned time, location and altitude.
This distant encounter is referred to informally as "the goodbye kiss" by mission engineers, because it provides a gravitational nudge that sends the spacecraft toward its dramatic ending in Saturn's upper atmosphere.
The geometry of the flyby causes Cassini to slow down slightly in its orbit around Saturn.
This lowers the altitude of its flight over the planet so that the spacecraft goes too deep into Saturn's atmosphere to survive, because friction with the atmosphere will cause Cassini to burn up.
"Cassini has been in a long-term relationship with Titan, with a new rendezvous nearly every month for more than a decade," said Cassini Project Manager Earl Maize at NASA's Jet Propulsion Laboratory in the US.
"This final encounter is something of a bittersweet goodbye, but as it has done throughout the mission, Titan's gravity is once again sending Cassini where we need it to go," said Maize.
Cassini is ending its tour of the Saturn system with an intentional plunge into the planet to ensure Saturn's moons - in particular Enceladus, with its subsurface ocean and signs of hydrothermal activity - remain pristine for future exploration.
The spacecraft's fateful dive is the final beat in the mission's Grand Finale, 22 weekly dives that began in late April through the gap between Saturn and its rings. No spacecraft has ever ventured so close to the planet before.
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