As part of the trial, about 100 people will travel in a prototype shuttle on a route in Greenwich over the next three weeks.
With a speed of just over 16 Kilometres per hour, the vehicle travels with a computer-controlled system. It can seat four people and has no steering wheel or brake pedal.
However, there will be a trained person on board who can stop the shuttle if required during the tests.
Officials behind the project believe the shuttles could improve transport links in Greenwich.
Passengers could begin using the system by 2019 on a trial basis and it may eventually be rolled out elsewhere, 'BBC News' reported.
During the trial, with the help of five cameras and three lasers the shuttle will navigate a two-mile riverside path near London's O2 Arena.
The shuttle can see up to 328 feet ahead and comes to a steady stop if it detects something in its path - although it can also apply an emergency brake if required.
"It's been designed to be safe and fail-safe specifically in a pedestrianised environment," Mr Smith added.
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