The girl, identified as Nazeeran, was speaking with her husband-to-be Shahid in Nayi Wahi village in the suburbs of Ghotki town when her uncle spotted them.
The uncle opened fire on them out of anger, Express News reported.
According to police, the victims were each other's cousins and the incident was a case of 'honour killing'.
Two suspects, both of whom happen to be the girl's uncles, have been arrested so far.
Honour killings are pandemic in Pakistan, and women are its predominant victims.
In November, a newly-wed couple in Sindh province who married without the consent of their elders were killed allegedly on the orders of a jirga (village elders).
More Pakistani women are murdered at the hands of close family members for supposed immoral behaviour than Pakistani civilians are killed by terrorism, the report said.
The Human Rights Commission of Pakistan (HRCP) has reported an average of 650 honour killings annually over the past decade. But since most go unreported, the real number is likely to be much higher, the report said.
Get the latest election news, live updates and election schedule for Lok Sabha Elections 2019 on ndtv.com/elections. Like us on Facebook or follow us on Twitter and Instagram for updates from each of the 543 parliamentary seats for the 2019 Indian general elections.