Ms Powell Jobs, an activist, is the founder and president of an organisation called Emerson Collective that focuses on "removing barriers" to "education, immigration reform (and) the environment".
The contents of the meeting were not immediately clear but, according to White House spokesperson Lindsay Walters, she was slated to speak with Trump about "education and immigration".
The California activist for years has supported the Dream Act, a bill that failed in the Senate and that would have legalised the status of tens of thousands of undocumented migrants who came to the US as young children - the group known as "Dreamers".
"We cannot be silent. Too much suffering already. America wants common-sense immigration reform, not mass deportation," Ms Powell Jobs had said earlier about Mr Trump's executive orders to toughen US immigration policy.
We cannot be silent.Too much suffering already. America wants common-sense immigration reform, not mass deportation. https://t.co/Mb21eh05DZ- Laurene Powell (@laurenepowell) February 19, 2017
"This action against immigration and refugees will go down in history as a source of national shame. Speak up, speak out. Do not accept hate," she tweeted after Mr Trump signed an executive order to create more detention centres for undocumented migrants and to accelerate deportations.