The suspect, who was shot by police and arrested moments after the rampage on the Lower West Side of Manhattan, left a note saying he carried out the attack in the name of the terrorist group ISIS, the New York Times and CNN said.
The death toll paled in comparison to dozens killed in similar assaults last year in France and Germany. However, it was still the bloodiest single attack on New York City since Sept. 11, 2001, when suicide hijackers crashed two jetliners into the World Trade Center, killing more than 2,600 people.
The Twin Towers site of the Sept 11 attacks was just a few blocks from the scene of the carnage left when the suspect allegedly swerved the pickup onto a path filled with pedestrians and bicyclists on a sunny, crisp autumn afternoon.
The vehicle mowed down everyone in its path before slamming into the side of a school bus.
The man then exited the vehicle brandishing what appeared to be a pair of handguns before he was shot in the abdomen by a police officer. Authorities said they recovered a paint-ball gun and a pellet gun from the scene.
The attack, which left crumpled bicycles scattered along the path and victims writhing on the ground, was over in seconds.
In addition to the eight fatalities at least 11 people were hospitalized for injuries described as serious but not life-threatening. That excluded the suspect, who underwent surgery for gunshot wounds.
Police declined to publicly identify the man, but a source familiar with the investigation said his name was Sayfullo Saipov, 29. He reportedly lived in Paterson, New Jersey, a one-time industrial hub about 25 miles (40 km) northwest of lower Manhattan.
He had rented the pickup from a Home Depot hardware store which, according to media accounts, was located in Passaic, just south of Paterson.
Argentine friends among dead
Six victims were pronounced dead at the scene and two more at a nearby hospital, Police Commissioner James O'Neill said.
Five of the dead were Argentine tourists, visiting New York as part of a group of friends celebrating the 30th anniversary of their high school graduation, the government there said. Belgium's foreign minister said a Belgian citizen was also among those killed.
Despite the attack, thousands of costumed Halloween revelers turned out hours later for New York City's main Halloween parade, which went on as scheduled on Tuesday night with a heightened police presence just a few blocks away.
Uzbekistan's President Shavkat Mirziyoyev told US President Donald Trump his government would do all it could to help investigate the "extremely brutal" attack.
Authorities late on Tuesday surrounded a house in Paterson where, according to the New York Times, Saipov was believed to have lived. Paterson, known for its large immigrant population, is home to about 150,000 people, including 25,000 to 30,000 Muslims.
ABC News reported that Saipov had lived in Tampa, Florida. A check of court records related to a traffic citation that Saipov received in eastern Pennsylvania in 2015 showed he listed addresses then in Paterson and Cuyahoga Falls, Ohio.
CNN and other media outlets, citing police officials, reported that the suspect shouted "Allahu Akbar" - Arabic for "God is greatest" - when he jumped out of his truck.
Although authorities from the mayor's office to the US Department of Homeland Security all swiftly branded the attack an act of terrorism, New York Governor Andrew Cuomo stressed that the suspect was believed to have acted alone.
Asked whether the suspect had been known to authorities before the attack, Cuomo said in a CNN interview: "It's too early to give you a definitive answer."
The New York Times said investigators quickly recognized Saipov had come to the attention of law enforcement in the past. It cited three officials as saying federal authorities knew of Saipov from an unrelated probe, although it was unclear whether that was because he had ties to someone who was under scrutiny or because he was the target of an investigation.
US Representative Adam Schiff, the ranking Democrat on the House Intelligence panel, told MSNBC in an interview that authorities were not aware of any other suspects, but that finding any such links would be a priority.
"It's still I think far too early to say" whether the suspect was radicalized before he came to the United States years ago or shifted once he was already here, or acted on his own rather than at the behest of an organized group, he said.
US President Donald Trump, who has pressed for a ban on travelers entering the United States from some predominantly Muslim countries, said on Twitter that he had ordered Homeland Security officials to "step up our already Extreme Vetting Program. Being politically correct is fine, but not for this!"
He also criticized the US visa system, blaming Democrats and saying that he wanted a 'merit based' program for immigrants to the United States.
(Reporting by Dan Trotta and Gina Cherelus in New York; Additional reporting by Jonathan Allen and Anna Driver in New York, Dan Whitcomb in Los Angeles, Mark Hosenball in Washington; Writing by Steve Gorman; Editing by Paul Tait and Chizu Nomiyama)