The train with 139 passengers and eight crew members aboard was traveling between New York and Miami when it collided with the freight train and derailed, Amtrak said in a statement.
"Amtrak Train 91, operating between New York and Miami, came in contact with a CSX freight train at around 2:35 a.m. in Cayce, South Carolina," Amtrak said in a statement on its website. "The lead engine was derailed, as well as some passenger cars."
The train was part of Amtrak' Silver Star Service and was headed for Miami, local media reported.
"The injuries range from cuts and bruises to severe broken bones. All the injured have been transported to local hospitals," said SCEMD public information officer Derrec Becker.
Amtrak and the Lexington County Sheriff's officials were not available for immediate comment.
(This story has not been edited by NDTV staff and is auto-generated from a syndicated feed.)
Get Breaking news, live coverage, and Latest News from India and around the world on NDTV.com. Catch all the Live TV action on NDTV 24x7 and NDTV India. Like us on Facebook or follow us on Twitter and Instagram for latest news and live news updates.