The single-engine Cessna went down and caught fire behind a home in a heavily-wooded area of the Midwestern state at about 9:10 pm local time on Saturday, the Indiana State Police said in a statement.
The crash "claimed the lives of all three people on board" as well as a dog, it said.
"A second dog survived the crash and showed up at a nearby residence. The dog was taken to a local veterinarian to be treated for injuries," the police said.
The plane was flying from Kansas City, Missouri, to Frederick, Maryland.
Get Breaking news, live coverage, and Latest News from India and around the world on NDTV.com. Catch all the Live TV action on NDTV 24x7 and NDTV India. Like us on Facebook or follow us on Twitter and Instagram for latest news and live news updates.