A year after the White House boycotted the annual dinner, the Director of Strategic Communications, Mercedes Schlapp, and her husband, conservative activist Matt Schlapp, were among those who marched out of the ballroom on Saturday night at the Washington Hilton long before Mr Wolf's keynote routine was over, reports Politico news.
Footage broadcast live on cable TV networks showed Ms Sanders sitting at the head table on stage stone-faced, wincing and at times raising her eyebrows as Ms Wolf compared her to a character on the dystopian "Handsmaid's Tale" and to an "Uncle Tom" for white women.
"I actually really like Sarah. I think she's very resourceful. But she burns facts and then she uses that ash to create a perfect smokey eye," Ms Wolf joked about Sanders. "Like maybe she's born with it, maybe it's lies. It's probably lies."
Ms Wolf laced into Mr Trump and repeatedly brought up his comments from the "Access Hollywood" tape where he spoke of groping women.
Ms Wolf opened her act with the line: "Good evening, here we are at the White House Correspondents' Dinner; like a porn star says when she's about to have sex with Trump, let's get this over with."
Ms Wolf's other targets included Vice President Mike Pence, White House counsellor Kellyanne Conway and the president's personal lawyer, Michael Cohen, Politico reported.
Former White House Press Secretary Sean Spicer deemed the evening a "disgrace" in a tweet, to which Ms Wolf replied: "Thanks!"
New York Times reporter Maggie Haberman, who was honoured during the dinner for her reporting, said Sanders' refusal to walk out amid the barbs was "impressive".
Besides the administration, Ms Wolf also hit out at the media but excluded the print media, because "it's illegal to attack an endangered species".
For the second year in a row, Trump avoided one of the annual highlights for a profession he has routinely called "the enemy of the American people".
On Saturday, he was at a campaign rally in Michigan where he said a possible meeting between him and North Korea's Kim Jong-un would take place in the next "three or four weeks".
Begun in 1921, the White House Correspondents' Association annual dinner has been attended by every President at least once during their term in office, beginning with President Calvin Coolidge in 1924.