Police have taken one man in custody (File Photo)
Several people have been injured in downtown Manhattan, and police confirmed that they were responding to reports of shots fired.
One person is reportedly in custody. The incident took place in the are of Chambers and West Streets in the upmarket TriBeCa neighbourhood.
Here are the live updates of the situation in Manhattan:
US President Donald Trump tweeted calling the New York attacker as 'very sick,' 'deranged person'
The suspect reportedly held out imitation firearms when he stepped out of his vehicle.
NYPD have reported that the suspect is in custody.
According to another witness, a white pickup truck was seen speeding down the West Side Highway, hitting several people on the way. The witness also reported hearing nine or ten shots being fired, but was unsure where they came from.
US media report a gunman opened fire from a vehicle near a high school. Witnesses say they saw a car crash and one person exit one of the vehicles with two guns before they heard shots being fired.
New York Police Department have said one person is in custody. Investigations are ongoing.