The blast is suspected to have taken place on the second floor of a building.
At least three people were killed and 15 others suffered injures in an explosion near Maskan Chowrangi in Karachi's Gulshan-i-Iqbal area on Wednesday, according to officials from the Edhi Foundation.
All injured have been taken to Patel hospital, according to a Dawn report.
The nature of the blast has not yet been ascertained. However, Mubina Town police SHO said that it "seems to be a cylinder blast", adding that the bomb disposal squad is arriving to verify the cause of the explosion.
The blast is suspected to have taken place on the second floor of a building. Eyewitnesses reported that windows of nearby buildings as well as some vehicles were also damaged.
A day earlier, five people were wounded when a bomb exploded at the entrance of a bus terminal near Sheerin Jinnah Colony.