Israel has launched airstrikes targeting central and western Iran in response to missile fire from Tehran, raising the possibility of a return to heavy fighting and complicating mediation efforts to reach a potential deal to end the US-Israeli war with Iran. Tehran's IRNA news agency reported that at least "two powerful explosions" were heard in Tehran and at least three explosions were heard in the cities of Isfahan, Karaj and Tabriz. Later, the Israeli army said it struck a petrochemical plant in Iran's Mahshahr. Iran's Revolutionary Guard said they retaliated by launching attacks on the Israeli air bases at Nevatim and Tel Nof. Iran closed the airspace around Tehran's Imam Khomeini International Airport, the country's main airfield, after the Israeli attack. Data from Flightradar24 showed civil airspace emptied from Israel to Iran as Tehran and Tel Aviv traded strikes. Tehran has also warned that all US bases in the Gulf are being considered legitimate targets by Tehran as Israel continues attacks on its territories, according to news agency Reuters.