Confirming the visit by Army Gen. Martin Dempsey, the chairman of the U.S. Joint Chiefs of Staff, the Israeli Defense Ministry did not give his agenda for talks with Israelis - but Iran is expected to be at the top.
Israel considers a nuclear-armed Iran to be an existential threat because of its nuclear program, missile capabilities, support for anti-Israel militants in Lebanon and Gaza and frequent references by its president to the destruction of Israel.
Israel has repeatedly hinted it might take military action if international sanctions fail to stop Iran's nuclear development.
The U.S., Israel and other Western nations believe Iran is developing atomic weapons. Tehran insists its nuclear program is for peaceful purposes.
Dempsey's visit will be his first official trip to Israel since he assumed command of the joint chiefs on Sept. 30.
On Thursday President Barack Obama and Israeli Prime Minister Benjamin Netanyahu discussed the Iran situation in a telephone conversation.
The Obama administration is concerned that Iran's recent claim that it is expanding nuclear operations with more advanced equipment may push Israel closer to a strike.
Last week, an Iranian nuclear scientist was killed in a car bombing in Tehran. There has been no claim of responsibility, but Iran has accused the U.S., Israel and Britain of being behind the killing. Several leading Iranian nuclear scientists have been killed in recent years.
The killing in Tehran came a day after Israeli military chief Lt. Gen. Benny Gantz was quoted as telling a parliamentary panel that 2012 would be a "critical year" for Iran - in part because of "things that happen to it unnaturally."
Israel has not commented publicly on the scientist's death.
The U.S. and its allies are pressuring Iran to halt uranium enrichment, but Iran appears to be attempting to expand operations.
The U.S. is also angered by an Iranian court's death sentence of a U.S. citizen and its threats to block the strategic Strait of Hormuz, the passage for one-sixth of the world's oil.
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