The attack targeted the Palace of Justice in central Damascus near the Old City. State news agency SANA said several others were wounded in addition to the initial death toll of 25.The bomber set off his explosive device at 1:20 p.m. (1120 GMT) as the police tried to search him and stop him from entering the building, state television cited the Damascus police chief as saying.
The explosion hit the courthouse "at a time when the area is crowded" with lawyers, judges and civilians, harming a large number of people, Ahmed al-Sayyid, a senior state legal official told state-run al-Ikhbariya TV.
No further details were immediately available.
On Saturday, scores of people, most of them Iraqi Shi'ite pilgrims, were killed in a double suicide attack in Damascus claimed by an alliance of jihadist groups known as Tahrir al-Sham.
(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)