Otero fought back tears, telling journalists that she was "very happy" to have won.
Eight-year-old Spanish girl Sofia Otero on Saturday won the best acting prize at the Berlin Film Festival for her role in the film "20,000 Species of Bees".
In the feature debut by Spanish director Estibaliz Urresola Solaguren, Otero plays a nine-year-old child who was born a boy but who considers herself a girl.
Collecting the prize, Otero fought back tears, later telling journalists that she was "very happy" to have won.
"I want to dedicate my life to acting," she said.
Director Urresola Solaguren said it was important for her to pick a girl to play the role and not a boy.
"It is easier for her. She's a really intelligent girl," she said.
Gender and identity issues were the focus of several films awarded at the festival on Saturday.
The prize for best supporting performance was awarded to Austrian transgender actress Thea Ehre for "Till the End of the Night".
The movie, by German filmmaker Christoph Hochhaeusler, is a love story between a gay police officer and a transgender person against the backdrop of an investigation into a drug dealer.
Picking up the prize, Ehre had a special message for her parents.
"Thanks for supporting me, for always (giving) me the space to be what I wanted."
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